Shaker potassium channel gating. III: Evaluation of kinetic models for activation.
نویسندگان
چکیده
منابع مشابه
Shaker Potassium Channel Gating Evaluation of Kinetic Models for Activation III :
AaSTgACT Predictions of different classes of gating models involving identical conformational changes in each of four subunits were compared to the gating behavior of Shaker potassium channels without N-type inactivation. Each model was tested to see if it could simulate the voltage dependence of the steady state open probability, and the kinetics of the single-channel currents, macroscopic ion...
متن کاملShaker potassium channel gating. III: Evaluation of kinetic models for activation
Predictions of different classes of gating models involving identical conformational changes in each of four subunits were compared to the gating behavior of Shaker potassium channels without N-type inactivation. Each model was tested to see if it could simulate the voltage dependence of the steady state open probability, and the kinetics of the single-channel currents, macroscopic ionic curren...
متن کاملShaker potassium channel gating. II: Transitions in the activation pathway
Voltage-dependent gating behavior of Shaker potassium channels without N-type inactivation (ShB delta 6-46) expressed in Xenopus oocytes was studied. The voltage dependence of the steady-state open probability indicated that the activation process involves the movement of the equivalent of 12-16 electronic charges across the membrane. The sigmoidal kinetics of the activation process, which is m...
متن کاملShaker potassium channel gating. I: Transitions near the open state
Kinetics of single voltage-dependent Shaker potassium channels expressed in Xenopus oocytes were studied in the absence of fast N-type inactivation. Comparison of the single-channel first latency distribution and the time course of the ensemble average current showed that the activation time course and its voltage dependence are largely determined by the transitions before first opening. The op...
متن کاملActivation of Shaker Potassium Channels III. An Activation Gating Model for Wild-Type and V2 Mutant Channels
A functional kinetic model is developed to describe the activation gating process of the Shaker potassium channel. The modeling in this paper is constrained by measurements described in the preceding two papers, including macroscopic ionic and gating currents and single channel ionic currents. These data were obtained from the normally activating wild-type channel as well as a mutant channel V2...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1994
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.103.2.321